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From the the theme files you'll be able to manage the main structure of the site along with the main structural design of the different blocks you can activate. Along with that, each module has a series of templates of their own which can be modified to have the content display like you want, it's not very easy but it's not impossible either, among all the cms I have seen XOOPS is the most manageable and easiest to customize in design. One of the most customized designs I've seen is
http://www.fantasyfootball.com/ , you can have that as an example of how XOOPS can be.
You should try the zeta reticuli theme and learn from it, it's the most advanced structure in themes I've seen so far.
www.polymorphee.com
www.xoopsdesign.com