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I'm having exactly the same trouble, only with XOOPS 2.2 and in my case I do see a click button under the message. However, clicking on it has no effect (only a message for a while saying that it's making a connection, but then it comes back to the same place).
It's strange, I've updated to 2.2 a few days ago and everything went fine, accesing to the admin area many times before without this problem. Don't know why all of a sudden the system decides that this is my first time to the admin area.
Permissions of my cache directory are also ok.
Sorry, not much of a help, but at least I hope it makes you feel not to be the only one in the world having this (I thought I was, before reading your post; one always thinks so, but never is).