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another thing to add is that it is more 'secure' than the majority of nuke forks.
As far as the 'upload' thing....there are many modules for creating custom forms, and most all of the forum modules now include file attachment ability with the post, as do some of the blog modules...
If your looking to just be able to upload and manage files on the server with users, there is a module called VideoBB that seems to do that well.
Most everything that is XOOPS compliant is 'user friendly' and is basically automated.
Installing new modules only requires uploding it and hitting a button or two...so yes, user friendly on the admin side as well.
Start with version 2.0.13.1, as that is the most stable version with the most mods and support currently.
Happy Xoopsing!