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Not without hacking, and I don't beleive there are any plans to support MS-SQL straight out of the box either. There have been a few guys trying to put together some hacks to get XOOPS to work with MS-SQL, but I have no idea where they are up to. Do a search and you should find some info. Be aware though that using hacks are not recommended for those new to this and that any support offered from these forums will be serverly limited.