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I am trying to find that balance. At times our site gets so busy that a blank white page comes up. I dont know what causes it, but my guess is that it either exceeded the number of DB connections, or the scripting engine couldnt keep up. I havnt seen the problem since turning on the caches (I set most of them to 1 hour). I backed most of them off to between 1 and 30 minutes. Hopefully that will stike a good balance.