Do the file check (see release notes), to see if all files were update correctly (errors for moved xoops_lib and xoops_data and deleted install directories are normal). Verify the allowed port for smtp.
I don't think you can use the profile module to inspect not yet activated accounts. I think you need a URL of the edit user from system admin to do that /modules/system/admin.php?fct=users&op=users_edit&uid=12345