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when you are in the group configuration area in the admin panel, you will see checkboxes for all of the installed module. ideally you want to have your entire site setup and configured how you want it to be for public use and have all the module you decide to use installed. from there, you need to determine what you want each group to have access to (write it out is easy). In the properties for each group, check the boxes that correspond to the blocks you want group to have access to, and the module you want them to access. Forget about how the groups relate to one another, because they don't. For example (i will use my site as a relational factor):
Registered users only have access to very basic things like faq, partners, news, forum, and links, and no special blocks.
Basic members have access to all that plus the gallery, sections, and freecontent module, and can see 'top' blocks.
premeire members have access to all of the above plus downloads, module A and module B and all blocks other than those reserve for admins such as waiting content etc.
In addition to that, some modules allow you to control rights to subsections within them, such as Xgallery, wsproject, and so on, so you would set access control separately there if needed.
I hope this make sense to you. My english is not #1 so I have articulated to the peak of my ability.