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I understand what you are saying, under certain situations you are probably right. I don't think you should exclude the 14% or so who use 800 X 600 resolution or the 25% or so that use a higher resolution.
When I go to a site and have to scroll sideways, if I even notice it (most of the time I will), unless I am there for something special, I will just go somewhere else and be pissed that they made it one way, and I know the difference. Most people using the Internet don't know the difference, so they just think the site was designed poorly, or worse yet don't even see part of your site.
Then the other end, I don't want to see a site with 2 or 3 inches of nothing on each side. To me that is unprofessional looking. We must remember that most people coming to our sites in most cases don't know much about how things work, they just notice how they look. I basically hate to scroll sideways or see my screen not being totally used, thats why I think everything should be designed to be universal, even if it means changing the content to fit right.
Just my thoughts, I do see what you are saying, I guess it depends on who you want visiting your site, I want everyone, I don't care what they use to get there, I feel that with a fixed width site you are telling many people you don't care what they think, same with the mozilla thing, many sites I go to look like crap because I use mozilla and the webmaster doesn't care or know how their site looks to me. So I stay away from those sites.
Just something to think about
John