I have not been able to apply it, since the upgrader seems to think I'm still at 2.0.18.2 and want to perform all the upgrades since then. I'm terrified of performing a series of upgrades I've already performed to a live server, so I'll likely wait until the 'RC' suffix has been dropped before trying again. Some of you may want to try it out, though, as it seems fixing the User Profile module was a major part of this bug fix upgrade.