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I had the same problem, or similar enough that this fixed it for me too. Not sure what causes that table to corrupt (possibly because the hard-drive got full, oops).

Thanks!

I was wondering if maybe it was execution time, that mailing so many people was taking too long and the script timing out.

OK, I had the same problem, for a slightly different reason.
RedHat 9.0, freshly up2date, php-4.2.2.. but I then installed MySQL 4.0.18 (NOT 3.23, which is what XOOPS says it needs on its install wizard/druid pages).
OK, this shouldnt have been a problem, but php-mysql wasnt installed... weird, ok, I had NO MySQL functions.. but wait, it seems to want the MySQL RPM (according to synaptic anyway), which is from MySQL 3!

Short solution, install MySQL-shared-compat-4.0.18-0.i386.rpm, which includes the specific lib file that 3.23 provided, and PHP still links to. Now I have finally seen the light, well, the next page of the installation anyway, and I'm eagerly awaiting to find out if this was worth the trouble. But then, the learning was worth the price of admission, eh?