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To my simple mind, Fixed size is confining and restrictive. Not everyone has the same size screen, same ability to see, etc.
It's much better to establish a min-width for a screen allowing design controls while at the same time allowing infinite max-width... I think you should use liquid or wireframe css with resizable fonts. Oh and DO NOT use tables.
So far as I can tell anything else is old school. If you want to read more you can go to:
http://www.w3.org/btw. Will I agree all this has to be simple. Like James, I'm trying to make that work. Easy Liquid/Wireframe CSS... what a concept!