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@matthewordie,
The directory location info is in the ./mainfile.php file.
You'll need to check XOOPS_ROOT_PATH, XOOPS_PATH, XOOPS_VAR_PATH, and XOOPS_TRUST_PATH to make sure they're correct.
You will also want to clear the cache(s) - go into Administration => Maintenance in the control panel and then clear all three caches. You might also want to clear the sessions table while you're there.