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Just speaking from experience here, but I've seen times where this will work, and times when it will not. If you have a local copy of your site to test on, that would be the best way to go. If not, I recommend that you apply the patches in order, one at a time.
Of course, I strongly recommend backing up your site before trying anything.
Best Regards,
James
Insanity can be defined as "doing the same thing over and over and expecting different results."
Stupidity is not a crime. Therefore, you are free to go.