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I've been through the entire directory structure looking for altered or new files, and the only thing with todays date was in the cache folder.

We only allow photos with a max size restriction put on and looking in upload there isn't anything in there that is big in size.

In _users in the db there were 2 new entries user23423 and user9846 and new users on the site need to be approved, and we reject anyone that submits a userid like that.

Woohoo...it's back.

I finally got back to the admin page, and the blocks that were visible all had 0's in the left block column, so I renumberd the blocks, saved it, boom the site reappeared!

Right now I have no idea how it happened as other than running XOOPS care on it's own, I've not been into the database at all lately.

Very strange, db related for sure, and I want to thank the members that responded helping me poke around the site.