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If you have webmail for you domain, then these settings usualy work:
Method: SMTP
Path: /usr/sbin/sendmail
(To verify, this is indicated in your site admin panel)
Host: localhost
(localhost is literally the word localhost and NOT an alias for an ip or hostname)
User: This is the username for logging in with webmail, has the form of an email address.
Password: Password for webmail.
From address: the same as user.
From name: to choose
With webmail on a domain, there are different levels. There is a login from the site admin panel, which uses the site admin name and password and gives access to all email boxes.
And there is a seperate login for each box. These box' credentials are to be used above.