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Ok.... Here's how you do it.
Say you have /home/mywebsite/public_html/
Upload your XOOPS installation there and install it, etc.
Make a copy of your mainfile.php and rename it to ABC.mainfile.php
Edit mainfile.php to have the modified code.
Point
http://www.ABC.com to /home/mywebsite/public_html/
Basically when you goto
http://www.ABC.com it will first goto read mainfile.php but mainfile.php has code in it to grab the domain name ABC and then direct it to ABC.mainfile.php
Next make a copy of the database and the ABC.mainfile.php but call it DEF.mainfile.php
Edit DEF.mainfile.php with the new database information.
Point
http://www.DEF.com to /home/mywebsite/public_html/
Now when you goto
http://www.DEF.com it will grab the information from DEF.mainfile.php
For every other site you want running of the same install just make a new copy of the database and a new mainfile.php to match it.