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Hi,
First thing to do is make sure that the /cache, /templates_c and /uploads folders are CHMODed to "777", i.e. writeable.
Secondly, and this is probably the main cause, you need to make sure that mainfile.php has:
1. the correct definitions for the XOOPS_ROOT_PATH & XOOPS_URL (& XOOPS_TRUST_PATH if you are using the Protector 3 module).
The ROOT_PATH will be the physical path on the server to your customer's webspace and the XOOPS_URL will be "virtual". (The TRUST_PATH will be physical, too).
2. the database name and database password correct.
Don't forget to CHMOD mainfile.php back to "444" once you've edited it.
I see for the link that you gave that your client uses newbb/CBB. What other modules are in use other than the basic XOOPS system and the bulletin board? This will help us to help you.
Hope this helps, and good luck.