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Hi,
I'm not using 2.2.x, but ...
giving more information about your setup may help - web server, version, apache modules and so on...
In general - check the log options in configs and set them to fill log, then look at web server logs, if you have mod_sec - disable it (usualy it is set to return 403 Forbiden) and have a look at his logs. If you have chroot instalation, make shure you set the proper owner for files and folders. Try to enable php debug in XOOPS and see for clues.
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